July 26, 2022

Researchers have developed a method for altering one class of antibiotics, using microscopic organisms that produce these compounds naturally. The findings could lead to more efficient production of antibiotics that are effective against drug-resistant bacteria.

Rosa Vasquez and David Sherman collect samples at the Boiling River
June 30, 2020

Deep in the Peruvian Amazon Rain Forest, microorganisms are thriving within a river so hot, it boils. U-M graduate student Rosa Vásquez iexploring the Boiling River’s ecosystem, searching for genetic clues that explain how these organisms have evolved to survive in their scalding surroundings.

Structural overview of BvnE
May 18, 2020

An international team of researchers has decoded the complex process that fungi use to build an important class of bioactive compounds.

Amy Fraley and Tyler Beyett
September 30, 2019

The LSI Cubed funding program is spurring innovative, trainee-led research projects, and already resulting in high-impact scientific findings.

Representation of fungi and the structure of a natural product they make
September 23, 2019

Researchers have solved a nearly 50-year-old mystery of how fungi produce a large class of bioactive compounds, revealing a chemical reaction reaction that is nearly unprecedented in nature

David Sherman and Rosa Vasquez discuss images of the Boiling River
June 28, 2019

LSI researchers are traveling more than 3,500 miles from Michigan to the Mayantuyacu Community in Peru in search of the organisms that can survive in a river so hot, it boils.

January 24, 2019

Four teams of graduate students and postdoctoral fellows will soon launch their own cross-lab, interdisciplinary projects, with funding from the LSI Cubed program.

October 29, 2018

Three ground-breaking LSI projects are among the University of Michigan projects to be funded in the first round of investments from the Biosciences Initiative.

October 29, 2018

LSI researchers are part of a new, federally funded effort to understand and prevent toxic algal blooms that plague portions of the Great Lakes and impact freshwater sources around the world.

Lab beakers
August 2, 2018

With funding from the U-M College of Engineering's Blue Sky Initiative, a team of researchers is setting out to streamline the process for developing the next generation of antimicrobials.

June 18, 2018

Research collaboration reveals how a mutation in the MUTYH protein prevents it from doing its job repairing damaged DNA — and our DNA can function like an electrical wire, conveying important signals.

Structure of the HpiC1 Stigonemataceae cyclase
March 12, 2018

How one type of enzyme allows a microorganism to produce molecules with a wide range of potentially beneficial activities — from fighting insects to killing fungi.

LSI building
December 31, 2017

A round-up of media stories about LSI research and researchers from 2017.

Amy Fraley explores an ecologically diverse sites within the Maria la Gorda reef system in Cuba
December 17, 2017

Graduate student Amy Fraley recently joined faculty member David Sherman on his latest expedition in Cuba, where strict barriers have prevented access for nearly 60 years.

March 20, 2017

Postdoc Laura Mike, Ph.D., is targeting bacteria’s need to scavenge iron from its human host in order to survive.

March 13, 2017

Researchers have mapped the  complex chemistry involved in creating several types of bioactive compounds that are naturally produced inside bacteria. 


LSI building
December 31, 2016

A round-up of media stories about LSI research and researchers from 2016.

David Sherman and his daughter hold a U-M flag on Mt. Everest
September 22, 2016

David Sherman and his daughter traveled to Nepal in the search for microbes that produce beneficial molecules.

A biofilm
February 16, 2016

 A new class of anti-biofilm compounds derived from marine microorganisms that show promise against a drug-resistant bacterium commonly associated with hospital-acquired infections.

October 6, 2015

A team from the LSI, University of Illinois, Chicago, and University of Southern Denmark has identified a resistance mechanism against ketolides, a new type of antibiotics just entering widespread use.

Mangrove Tunicate (photo by Michael Schofield)
May 27, 2015

For decades, scientists have known that ET-743, a compound extracted from the mangrove tunicate — a kind of sea squirt — can kill cancer cells. Until now, its precise origins were a mystery.

June 24, 2014

Eli Benchell Eisman, a post-doctoral research fellow working in the lab of David Sherman in the LSI and a STEM-Africa Seed Scholar, spent ten weeks in Ghana investigating plant-based traditional medicines in hopes of ultimately developing new drugs.

Cryo-EM structure of the central enzyme in the assembly process that creates polyketides (Credit: Somnath Dutta)
June 18, 2014

Researchers at the LSI have obtained for the first time three-dimensional snapshots of the “assembly line” within microorganisms that naturally produces antibiotics and other drugs. 

May 16, 2014

Researchers at the LSI and the National Biodiversity Institute (INBio) in Costa Rica have discovered a new antibiotic that is active against both Methicillin-resistant Staphylococcus aureus (MRSA) and anthrax in laboratory tests.