Our lab uses a multi-disciplinary approach of structural biology, biochemistry and cell biology to study molecular mechanisms of proteins that function in intracellular trafficking.
Our current focus is on the endosomal-sorting complex required for transport (ESCRT), a multi-component protein machinery essential for a wide range of biological processes including cell surface receptor down-regulation, enveloped virus budding, cytokinesis and autophagy.
Our work has therapeutic implications for diseases such as cancer, viral infection and neuro-degeneration.
Zhaohui Xu, Ph.D.
Research Associate Professor, U-M Life Sciences Institute
Associate Professor, Biological Chemistry, U-M Medical School
Director, Undergraduate Training, U-M Life Sciences Institute