Normal and neoplastic cells are surrounded by a dense, fibrillar composite of extracellular matrix molecules that not only serve as a platform for cell adhesion, but also exert complex effects on cell differentiation, fate and function.
Our laboratory focuses on the characterization of both the proteolytic enzymes and the transcriptional programs that control extracellular matrix remodeling during growth and development, inflammation and cancer.
Stephen J. Weiss, M.D.
Research Professor, Life Sciences Institute
E. Gifford and Love Barnett Upjohn Professor of Internal Medicine and Oncology, U-M Medical School