We seek to understand how membrane-enclosed structures within our cells perform their specific jobs to maintain cell health. We are particularly interested in lysosomes, which not only play an important role in cellular 'waste management,' but also serve as a key decision-making center controlling cellular growth and survival. Loss of these functions can lead to wide range of diseases, including cancer and cardiovascular disorders.
Our lab combines state-of-the-art cryo-electron microscopy/tomography and cryo-confocal microscopy approaches with biochemical and cell biology methods to elucidate how lysosomes perform their functions and engage in clearance of pathological aggregates. We are also interested in structural characterization of lysosomal membrane transporters and channels.