Our Research

Our research program focuses on the structural biology and biophysics underlying microtubule-based intracellular transport through the use of cryo-electron microscopy, single molecule TIRF, and biochemistry.

Overarching questions of the lab:

  • How is specificity determined between motor proteins and cargo?
  • How are the activities of multi-motor complexes regulated?
  • What are the molecular consequences of neurodegenerative disease-causing mutations? 

Along the way, we are also developing cloud computing tools for cryo-electron microscopy to facilitate its adoption and to remove barriers for new users.