Our Research
The Ohi lab's research interest focuses on dissecting the structural organization of large macromolecular machines. Our goal is to use structure as a springboard to understand function within the context of cells.
Our laboratory uses single particle cryo-electron microscopy (cryo-EM) in combination with biophysical, biochemical, and genetic approaches to structurally and functionally characterize biologically important but structurally challenging molecular machines. We have exciting projects studying the machinery involved in gene regulation, bacterial pathogenesis, and membrane remodeling proteins.
Melanie Ohi, Ph.D.
News
With $1.5M award, U-M researchers gain new window into the inner workings of cells
Biosciences Initiative invests $45M in U-M research
Three ground-breaking LSI projects are among the University of Michigan projects to be funded in the first round of investments from the Biosciences Initiative.
Publication Highlights
Porta JC, Han B, Gulsevin A, Chung JM, Peskova Y, Connolly S, Mchaourab HS, Meiler J, Karakas E, Kenworthy AK, Ohi MD, Sci Adv (2022)
Caso GC, McClain MS, Erwin AL, Truelock MD, Campbell AM, Leasure CS, Nagel M, Schey KL, Lacy DB, Ohi MD, Cover TL, Infect Immun (2021)
Sheedlo MJ, Durie CL, Chung JM, Chang L, Roberts J, Swanson M, Lacy DB, Ohi MD, Elife (2021)
Fantin SM, Parson KF, Yadav P, Juliano B, Li GC, Sanders CR, Ohi MD, Ruotolo BT, Proc Natl Acad Sci U S A (2021)
McIlwain BC, Erwin AL, Davis AR, Ben Koff B, Chang L, Bylund T, Chuang GY, Kwong PD, Ohi MD, Lai YT, Stockbridge RB, J Mol Biol (2021)
Mousa JJ, Binshtein E, Human S, Fong RH, Alvarado G, Doranz BJ, Moore ML, Ohi MD, Crowe JE Jr, PLoS Pathog (2018)
Mittendorf KF#, Marinko JT#, Hampton CM, Ke Z, Hadziselimovic A, Schlebach JP, Law CL, Li J, Wright ER, Sanders CR*, Ohi MD*, Sci Adv (2017)
#co-first authors, *Co-corresponding authors
Pyburn TM, Foegeding NJ, González-Rivera C, McDonald NA, Gould KL, Cover TL, Ohi MD, Mol Microbiol (2016)
Frick-Cheng AE, Pyburn TM, Voss BJ, McDonald WH, Ohi MD, Cover TL, MBio (2016)
McDonald, NA, Vander Kooi, CW, Ohi, MD, Gould, KL, Dev Cell (2015)