Our Research
The Weisman lab uses cultured neurons, cell lines and yeast to study neurodegeneration and cancer, with the goal of determining the mechanisms of myosin V based transport and phosphoinositide signaling. The ultimate goal is to develop novel therapies for relevant diseases.
Our group uses aspects of biochemistry, molecular biology, cell biology, genetics and developmental biology to discover how cells function.
Lois Weisman, Ph.D.
News
Research Highlight: Scientists uncover unexpected function for an obscure enzyme, hinting at broader roles in multiple human disorders
An obscure enzyme that normally operates deep within cells is also playing an unexpected role close to the cell surface—and is even required for cell migration—according to new research from the Life Sciences Institute.
Cells rely on multiple controls to coordinate cargo delivery, new research shows
Researchers have uncovered a new twist in the complex process cells use to transport their molecular cargo.
Researchers identify new potential drug target for Huntington’s disease
New insights allowed researchers to ameliorate the effects of Huntington’s disease in a fruit fly model of the disease.
Publication Highlights
Wong S, Hepowit NL, Port SA, Yau RG, Peng Y, Azad N, Habib A, Harpaz N, Schuldiner M, Hughson FM, MacGurn HA, Weisman LS, Current Biol (2020)
Strunk, B.S, Steinfeld, N, Lee, S., Jin, N., Akemann, C., MacGurn, J.A, Mapp, A.K., Weisman, L.S, Roles for a lipid phosphatase in the activation of its opposing lipid kinase.” Mol Biol Cell (2020)
Singla A, Fedoseienko A, Giridharan SSP, Overlee BL, Lopez A, Jia D, Song J, Huff-Hardy K, Weisman L, Burstein E, Billadeau DD, Nature Communications (2019)
Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ, Elife (2017)
Jin N, Jin Y, Weisman LS, J Cell Biol (2017)
Yau RGW*, Wong S*, Weisman LS, J Cell Biol (2017)
