Our Research
In response to growth factors and nutrients, target of rapamycin (TOR) plays essential roles in a wide array of cellular processes including protein translation, gene transcription, apoptosis and autophagy. Dysregulation of the mammalian TOR (mTOR) signaling pathway is involved in the development of diseases including cancer and metabolic disorders.
Using biochemical and genetic approaches, we investigate the function and regulation of the mTOR signaling pathway and the role of mTOR signaling in disease.
Ken Inoki, M.D., Ph.D.
News
Oh, it's a switch
A long-term collaboration reveals the critical role played by the RNA binding protein LARP1 for mTORC1-mediated translation of an important class of mRNAs, including those that encode ribosome proteins.
Publication Highlights
Hong S, Freeberg MA, Han T, Kamath A, Yao Y, Fukuda T, Suzuki T, Kim JK, Inoki K, Elife (2017)
Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel AR, Inoki K, Mol Cell (2013)
Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL, J Clin Invest (2011)