In response to growth factors and nutrients, target of rapamycin (TOR) plays essential roles in a wide array of cellular processes including protein translation, gene transcription, apoptosis and autophagy. Dysregulation of the mammalian TOR (mTOR) signaling pathway is involved in the development of diseases including cancer and metabolic disorders.
Using biochemical and genetic approaches, we investigate the function and regulation of the mTOR signaling pathway and the role of mTOR signaling in disease.
Ken Inoki, M.D., Ph.D.
Roger C. Wiggins Collegiate Professor of the Life Sciences
Research Associate Professor, U-M Life Sciences Institute
Associate Professor, Division of Nephrology, Department of Internal Medicine, U-M Medical School
Associate Professor, Department of Molecular & Integrative Physiology, U-M Medical School