Our Research
Our laboratory investigates the mechanisms that regulate nutrient and energy metabolism in cells, tissues, and organisms.
We focus on elucidating how the metabolic properties of tissues are specified during development and reprogrammed in disease, dissecting the genetic and epigenetic mechanisms of metabolic regulation, and discovering novel secreted factors in systemic metabolic crosstalk.
Jiandie Lin, Ph.D.
News
When untethered, this signaling protein intensifies inflammation in obese mice, new study reveals
Researchers have discovered how a protein that is overproduced by fat cells in an obese state may be contributing to the demise of two immune cell types — and driving further metabolic disorders in the process
One cell at a time, researchers create a blueprint of liver cells in health and disease
Researchers have created a high-resolution picture of the cells at work inside a key hub of metabolism — the liver — and how individual cell types are reprogrammed in disease.
When the body is in overdrive, this liver hormone puts the brakes on metabolism, researchers find
Researchers have identified a hormone produced by the liver that tells the body to downshift its metabolism when it’s expending a lot of energy, revealing a potential target for treating metabolic disorders.
Publication Highlights
Zhao XY, Xiong X, Liu T, Mi L, Peng X, Rui C, Guo L, Li S, Li X, Lin JD, Nat Commun (2018)
Guo L, Zhang P, Chen Z, Xia H, Li S, Zhang Y, Kobberup S, Zou W, Lin JD, J Clin Invest. (2017)
Meng ZX, Gong J, Chen Z, Sun J, Xiao Y, Wang L, Li Y, Liu J, Xu XZS, Lin JD, Mol Cell (2017)
Wang GX, Zhao XY, Meng ZX, Kern M, Dietrich A, Zhou D, Okunade AL, Su X, Li S, Bluher M, Lin JD, Nat Med (2014)
Zhao XY, Li S, Wang GX, Yu Q, Lin JD, Mol Cell (2014)
Meng ZX, Li S, Ko HJ, Lee Y, Okutsu M, Yan Z, Kim JK, Lin JD, Nat Med (2013)