Precise control of the blood-clotting system is essential for maintenance of the circulation in all higher animals. Deficient function of this system can lead to fatal bleeding following even a minor injury, whereas overactivity of this system can produce unwanted blood clots, resulting in blockages to critical blood vessels, as occurs in such diseases as heart attack and stroke.
We study the genetics of blood clotting, the structure and function of key blood clotting proteins, and the processes regulating the cellular secretion of blood clotting and other proteins.
David Ginsburg, M.D.
Research Professor, U-M Life Sciences Institute
James V. Neel Distinguished University Professor and Warner-Lambert/Parke-Davis Professor, Departments of Internal Medicine, Human Genetics and Pediatrics, U-M Medical School
Investigator, Howard Hughes Medical Institute