Researchers have demonstrated that a natural compound produced by lichens can block the activity of a protein that is central to the gene-activation process. The research, conducted in human-derived breast cancer cells, points to this protein as potential therapeutic target.
Researchers are advancing a novel approach to developing antivirals against SARS-CoV-2, with support from the LSI’s Klatskin-Sutker Discovery Fund
New research is challenging a long-held understanding of how two types of cellular proteins cooperate to activate genes. The findings improve the possibility of targeting these interactions with small-molecule drugs.
In the Michigan Life Sciences Fellows program, May-Walt Fellow Brittany Morgan, Ph.D., has found a balance of independence and community that will serve her well as she prepares for her independent scientific career. Learn how this 'super postdoc' program is helping fellows get a step ahead in their early careers and developing the next generation of scientific leaders.
Four teams of graduate students and postdoctoral fellows will soon launch their own cross-lab, interdisciplinary projects, with funding from the LSI Cubed program.
Researchers have determined how to target a class of proteins that have long been considered too “fuzzy” to target with small molecules, opening the door to new drug-discovery projects.
Findings remove a barrier to developing potential therapies for cancer patients with poor prognoses.
In the last century, Michigan was a driving engine of America’s manufacturing economy. Today, programs like the Perrigo Undergraduate Fellowship at the LSI are helping to fuel a new knowledge-based economy in the state.
How fly fishing can help explain a new frontier of drug discovery
Researchers blocked the dysregulated signaling associated with a 'master transcription factor,' which controls many different cellular decisions, without compromising its other biologically important functions.
Anna Mapp, Ph.D. has been awarded the 2015 Emil Thomas Kaiser Award from the Protein Society. The award recognizes a recent, highly significant contribution in applying chemistry to the study of proteins.