Structure of lecithin-cholesterol acyltransferase
March 2, 2015

With the aid of X-ray crystallography, researchers at the University of Michigan have revealed the structures of two closely related enzymes that play essential roles in the body’s ability to metabolize excess lipids, including cholesterol.

February 12, 2015

Anna Mapp, Ph.D. has been awarded the 2015 Emil Thomas Kaiser Award from the Protein Society. The award recognizes a recent, highly significant contribution in applying chemistry to the study of proteins.

January 12, 2015

LSI researchers have identified how a promising drug in clinical trials for the treatment of obesity and related metabolic disorders improves the metabolism of sugar by generating a new signal between fat cells and the liver.

structure of PLCbeta3
December 9, 2014

How structural features of a critical enzyme found in the cardiovascular system influence its regulation of heart activity

colorful fat cells
November 17, 2014

LSI scientists have discovered how a previously unknown hormone serves as a messenger from fat cells to the liver and are investigating the potential of developing a new treatment for metabolic disorders.

November 6, 2014

LSI scientists have shown how a single neuron can perform multiple functions in a model organism, illuminating for the first time this fundamental biological mechanism and shedding light on the human brain.

October 29, 2014

LSI researchers uncover information about a little-known signaling lipid pathway that unexpectedly plays critical roles in neuronal synapses in humans.

Scientific graphic
October 27, 2014

LSI researchers have illuminated steps of the molecular mechanism that increases the overall output of cells during normal brain development

September 30, 2014

LSI researchers have described a new approach to discovering potential cancer treatments that requires a fraction of the time needed for more traditional methods.

June 24, 2014

Eli Benchell Eisman, a post-doctoral research fellow working in the lab of David Sherman in the LSI and a STEM-Africa Seed Scholar, spent ten weeks in Ghana investigating plant-based traditional medicines in hopes of ultimately developing new drugs.

A structural model of the beta2 adrenergic receptor-arrestin signaling complex (Credit: Duke University)
June 22, 2014

A team of scientists from U-M, Duke Medicine and Stanford University has determined the underlying architecture of a cellular signaling complex involved in the body's response to stimuli such as light and pain.

Cryo-EM structure of the central enzyme in the assembly process that creates polyketides (Credit: Somnath Dutta)
June 18, 2014

Researchers at the LSI have obtained for the first time three-dimensional snapshots of the “assembly line” within microorganisms that naturally produces antibiotics and other drugs. 

yeast in petri dishes
May 30, 2014

LSI researchers have discovered a key regulator of autophagy, the cellular recycling process involved in many human diseases. The finding illuminates potential new drug targets for cancer, neurodegeneration and other diseases.

May 16, 2014

Researchers at the LSI and the National Biodiversity Institute (INBio) in Costa Rica have discovered a new antibiotic that is active against both Methicillin-resistant Staphylococcus aureus (MRSA) and anthrax in laboratory tests.

Bing Ye
April 17, 2014

Researchers at U-M have shown that the specific connection of sensory neurons to the correct targets in the central nervous system in fruit flies is dependent on how active the neurons are.

March 11, 2014

LSI researchers have discovered a key enzyme responsible for regulating the final step in the movement of organelles during cell division and differentiation.

NS1 protein
February 6, 2014

A team of scientists at U-M and Purdue University has discovered a key aspect both to how the viruses replicate in the cells of their host and how they manipulate the immune system as they spread.  

Axons in development
June 5, 2013

U-M researchers have determined how a gene that is known to be defective in Down syndrome is regulated and how its dysregulation may lead to neurological defects, providing insights into potential therapeutic approaches to an aspect of the syndrome.

Drawing of a neuron
June 4, 2013

LSI reseachers have evidence that a single gene controls both halves of nerve cells, and their research demonstrates the need to consider that design in the development of new treatments for regeneration of nerve cells.

PCSK9. Image credit Emw via Wikipedia (CC BY-SA 3.0)
April 10, 2013

Targeting the transport mechanism for a destructive protein lowers blood cholesterol levels in mice.