Researchers blocked the dysregulated signaling associated with a 'master transcription factor,' which controls many different cellular decisions, without compromising its other biologically important functions.
LSI Director Roger Cone is among the new members of the National Academy of Medicine of the National Academies, one of the highest honors in the fields of health and medicine.
A transcription factor known as Snail1 can act as a “molecular bypass” that diminishes the natural tumor suppressing action of a gene called p53 in breast cancer patients.
David Sherman and his daughter traveled to Nepal in the search for microbes that produce beneficial molecules.
LSI researchers are breaking new ground in scientists’ quest to develop drugs that can target DNA transcription, which is dysregulated in a variety of diseases from cancer to diabetes.
Revealed: the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus’s reproduction and its interaction with a host’s immune system.
The first high-resolution snapshots of a deadly parasite's ribosome provide a detailed map of its structure to aid the design of new drugs.
Roger D. Cone, Ph.D., will serve as the new Mary Sue Coleman Director of the University of Michigan Life Sciences Institute, effective Sept. 1.
An LSI study identified a new type of alkaline sensor in nematodes.
Last week, health officials announced the first case in the U.S. of E. coli resistant to colistin, a “last resort” antibioti
New investments are accelerating an innovative approach to discovering potential cancer treatments that was developed at the LSI.
A new class of anti-biofilm compounds derived from marine microorganisms that show promise against a drug-resistant bacterium commonly associated with hospital-acquired infections.
A international team makes a key discovery about how the brain’s “garbage disposal” process works — and how little needs to go wrong in order for it to break down.
A round-up of media stories about LSI research and researchers from 2015.
The newest member of the LSI faculty aims to bridge the gap between the powerful chemistry developed over millions of years of evolution by bacteria, fungi and other natural organisms, and cutting-edge synthetic chemistry techniques.
Identified: a pathway in the liver, controlled by a protein known as BAF60a, that contributes to the negative effects of a high-fat diet by stimulating the production of bile — which helps the body to absorb more cholesterol and other fats from the foods we eat.
A chemical that could potentially be used in eye drops to reverse cataracts, the leading cause of blindness, has been identified by a team of scientists from U-M and their collaborators.
LSI faculty member Daniel J. Klionsky was awarded the 2015 van Deenan Medal from the Institute of Biomembranes at Utrecht University in The Netherlands.
A banana a day may not keep the doctor away, but a substance originally found in bananas and carefully edited by scientists could someday fight off a wide range of viruses, new research suggests.
Pedro Cuatrecasas, M.D., a renowned leader in the pharmaceutical industry and co-chair of the University of Michigan Life Sciences Institute Scientific Advisory Board, is scheduled to receive honorary degrees at Winter Commencement 2015.
A team from the LSI, University of Illinois, Chicago, and University of Southern Denmark has identified a resistance mechanism against ketolides, a new type of antibiotics just entering widespread use.
Studies using yeast genetics have provided new, fundamental insights into the cell-division cycle, researchers at the LSI reported.
Certain types of stem cells use microscopic, threadlike nanotubes to communicate with neighboring cells LSI researchers have discovered.
LSI research shows for the first time that the age-old temperature law does not apply equally to adults and developing young.