March 20, 2017

Alicia Buisst recently toured the LSI with members of the Leukemia and Lymphoma Society of Michigan, visiting to learn about the research of faculty member Ivan Maillard, whose work the society supports. In this personal essay, she connects the drive of basic science research to her journey as a blood cancer patient.

March 13, 2017

Researchers have mapped the  complex chemistry involved in creating several types of bioactive compounds that are naturally produced inside bacteria. 


Molecular illustration
February 17, 2017

LSI scientists identified a molecular switch that triggers a stem cell’s progeny to commit to generating only differentiated cell types by giving up its “stemness.”

February 17, 2017

LSI Director Roger Cone receives named professorship honoring the pioneering botanist Asa Gray. 

LSI building
December 31, 2016

A round-up of media stories about LSI research and researchers from 2016.

December 8, 2016

How fly fishing can help explain a new frontier of drug discovery

November 17, 2016

The new receptor protein has unusual characteristics that suggest potential future applications ranging from sunscreen to scientific research tools.

Yukiko Yamashita
November 11, 2016

LSI faculty member Yukiko Yamashita, Ph.D., honored for her significant contributions to the field of biology

C. Elegans (HeitiPaves / Thinkstock)
November 8, 2016

How chemicals that cause damaging oxidation to the nervous system may actually improve sensory function at low doses

Anna Mapp
November 1, 2016

Researchers blocked the dysregulated signaling associated with a 'master transcription factor,' which controls many different cellular decisions, without compromising its other biologically important functions.

Roger Cone
October 17, 2016

LSI Director Roger Cone is among the new members of the National Academy of Medicine of the National Academies, one of the highest honors in the fields of health and medicine. 

October 17, 2016

A transcription factor known as Snail1 can act as a “molecular bypass” that diminishes the natural tumor suppressing action of a gene called p53 in breast cancer patients.

David Sherman and his daughter hold a U-M flag on Mt. Everest
September 22, 2016

David Sherman and his daughter traveled to Nepal in the search for microbes that produce beneficial molecules.

Anna Mapp draws chemistry symbols on a window
September 15, 2016

LSI researchers are breaking new ground in scientists’ quest to develop drugs that can target DNA transcription, which is dysregulated in a variety of diseases from cancer to diabetes.

Zika Virus NS1 structure
July 19, 2016

Revealed: the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus’s reproduction and its interaction with a host’s immune system.

Structure of a ribosome
June 30, 2016

 The first high-resolution snapshots of a deadly parasite's ribosome provide a detailed map of its structure to aid the design of new drugs. 

Roger Cone
June 16, 2016

Roger D. Cone, Ph.D., will serve as the new Mary Sue Coleman Director of the University of Michigan Life Sciences Institute, effective Sept. 1.

Shawn Xu
June 16, 2016

An LSI study identified a new type of alkaline sensor in nematodes.

David Sherman
June 2, 2016

Last week, health officials announced the first case in the U.S. of E. coli resistant to colistin, a “last resort” antibioti

April 8, 2016

New investments are accelerating an innovative approach to discovering potential cancer treatments that was developed at the LSI.

John Tesmer and lab members
March 9, 2016

 Taking aim at a cancer's ability to spread.

A biofilm
February 16, 2016

 A new class of anti-biofilm compounds derived from marine microorganisms that show promise against a drug-resistant bacterium commonly associated with hospital-acquired infections.

brain illustration (wildpixel / Thinkstock)
January 26, 2016

A international team makes a key discovery about how the brain’s “garbage disposal” process works — and how little needs to go wrong in order for it to break down.

LSI building
December 31, 2015

A round-up of media stories about LSI research and researchers from 2015.

Dried pufferfish hanging in office
December 14, 2015

The newest member of the LSI faculty aims to bridge the gap between the powerful chemistry developed over millions of years of evolution by bacteria, fungi and other natural organisms, and cutting-edge synthetic chemistry techniques.