Antibody blocks dengue virus's NS1 protein from interacting with host cells
January 7, 2021

A team of researchers has discovered an antibody that blocks the dengue virus’s ability to cause disease in mice. The findings open the potential for developing effective treatments and designing a vaccine for dengue and similar diseases.

Anna Mapp, Ph.D.
December 18, 2020

Researchers are advancing a novel approach to developing antivirals against SARS-CoV-2, with support from the LSI’s Klatskin-Sutker Discovery Fund

Image credit: PNAS; (CC BY-NC-ND 4.0)
October 30, 2020

New research is challenging a long-held understanding of how two types of cellular proteins cooperate to activate genes. The findings improve the possibility of targeting these interactions with small-molecule drugs.

Shayamal Mosalaganti, Ph.D.
October 28, 2020

Shyamal Mosalaganti’s new research program at U-M will take advantage of the LSI’s cutting-edge cryo-ET resources to investigate how multi-protein cellular complexes perform their functions within the context of the cell environment — and how these functions contribute to health and disease.

Diogenes Lopez-Urioso
October 28, 2020

U-M program connects future scientists to the lab, the university and their goals

Regions of the Drosophila central nervous system that are activated in response to noxious stimulation
October 14, 2020

Researchers have uncovered a neural network that enables Drosophila melanogaster to convert external stimuli of varying intensities into a “yes or no” decision about when to act.

Artistic representation of budding yeast cells
September 10, 2020

Researchers have uncovered a new twist in the complex process cells use to transport their molecular cargo.

August 26, 2020

This year’s LSI Saltiel Life Sciences Symposium will examine innovative and creative research taking place to address scientific challenges across the biosciences. The two-day virtual event will offer a combination of full lectures and shorter talks from both external speakers and U-M investigators.

Rosa Vasquez and David Sherman collect samples at the Boiling River
June 30, 2020

Deep in the Peruvian Amazon Rain Forest, microorganisms are thriving within a river so hot, it boils. U-M graduate student Rosa Vásquez iexploring the Boiling River’s ecosystem, searching for genetic clues that explain how these organisms have evolved to survive in their scalding surroundings.

June 26, 2020

While many U-M labs were closed, new and current fellows in the Michigan Life Sciences Fellows program created opportunities to strengthen their network and develop professional skills.

Mouse neurons
June 16, 2020

New research reveals that one group of neurons controls various types of sighing, but they receive their instructions from different areas of the brain depending on the reason for the sigh.

Heat map of thermogenic fat cells (artistic rendering)
June 12, 2020

Researchers have discovered a new signaling pathway that prompts one type of fat cells to convert fat into heat.

Structural overview of BvnE
May 18, 2020

An international team of researchers has decoded the complex process that fungi use to build an important class of bioactive compounds.

May 13, 2020

Researchers have discovered how a protein that is overproduced by fat cells in an obese state may be contributing to the demise of two immune cell types — and driving further metabolic disorders in the process

SARS-CoV-2 spike protein binding to the human ACE2 receptor protein
May 7, 2020

U-M scientists are advancing a new antibody test to identify people who have been infected with the novel coronavirus that causes the COVID-19 disease.

Brittany Morgan, Ph.D.
April 24, 2020

In the Michigan Life Sciences Fellows program, May-Walt Fellow Brittany Morgan, Ph.D., has found a balance of independence and community that will serve her well as she prepares for her independent scientific career. Learn how this 'super postdoc' program is helping fellows get a step ahead in their early careers and developing the next generation of scientific leaders.

April 23, 2020

An international team of researchers has unveiled the precise shape of a key player in human metabolism, which could open the door to better treatments for obesity and other metabolic disorders.

April 14, 2020

A new data-processing approach offers a simpler, faster path to data generated by cryo-electron microscopy instruments, removing a barrier to wider adoption of this powerful technique.

Michigan Drug Discovery Logo
January 10, 2020

The University of Michigan and Sun Pharma Advanced Research Company (SPARC) have launched a partnership to accelerate the development of potential new medicines for a wide range of diseases. 

Michigan Drug Discovery Logo
December 9, 2019

The new director of Michigan Drug Discovery has big plans for how the initiative can continue to impact the university and the regional economy.

Zinc-finger antiviral protein in complex with RNA
November 11, 2019

A new study reveals how an antiviral protein in our cells latches onto foreign invaders, and how some viruses — including HIV — evade capture.

Isin Cakir, Ph.D.
October 31, 2019

Research investigator Isin Cakir, Ph.D., has been awarded the the 2019 Klatskin-Sutker Discovery Fund award to develop a suite of new molecules targeting obesity.

cryo-EM 3D reconstruction of the protein P-Rex1 bound to G-beta-gamma
October 16, 2019

Researchers have shed light on the molecular details of a protein-protein interaction that drives cell movement and cancer metastasis

Amy Fraley and Tyler Beyett
September 30, 2019

The LSI Cubed funding program is spurring innovative, trainee-led research projects, and already resulting in high-impact scientific findings.