Artistic representation of a brain with neurons connecting and firing
November 3, 2021

Scientists have identified how a protein in the brain uses information about the body’s energy balance to regulate growth rate and the onset of puberty in children.

September 26, 2021

University of Michigan faculty member Alison Narayan has received the American Chemical Society’s Arthur C. Cope Scholar Award for excellence in organic chemistry.

The common model species C. elegans can sense airbornewaves
September 22, 2021

A common model species can sense sound waves without ears, providing a new tool for studying auditory sensation.

Ciria Hernandez working in the Center for Chemical Genomics
July 29, 2021

Two new research projects are moving forward at the U-M Life Sciences Institute, with support from philanthropic funds established specifically to high-risk, high-reward research.

Voices of the LSI
July 7, 2021

A quarterly column on the LSI’s work to cultivate a diverse, equitable and inclusive climate

June 30, 2021

Researchers have demonstrated that a natural compound produced by lichens can block the activity of a protein that is central to the gene-activation process. The research, conducted in human-derived breast cancer cells, points to this protein as potential therapeutic target.

MC3R, AgRP and VGAT mRNA expression in the arcuate nucleus of a mouse brain
April 21, 2021

Scientists have identified a protein called the melanocortin 3 receptor as a potential drug target for treating obesity and eating disorders such as anorexia nervosa.

Artistic representation of a neural network
March 29, 2021

A new study from the University of Michigan offers insights into how neural circuitry in the brain operates and responds to feeding and hunger in real-time.

Mary Sue Coleman attends and LSI celebration in 2008
March 25, 2021

The building that houses the LSI will be named Mary Sue Coleman Hall. This naming recognizes her enduring commitment to the sciences and her role in spearheading the Life Sciences Institute, as well as her highly successful tenure as president of U-M.

Bing Ye discusses labwork with postdoctoral researcher Elizabeth Cebul
March 19, 2021

As we marked our first “Panniversary,” LSI professor and research associate dean Bing Ye reflected on how the institute has navigated a year of reduced research efforts, and the potential long-term impacts — both good and bad — on the scientific enterprise.

Cells fluorescing green in the presence of opioids
March 17, 2021

Researchers in the lab of Wenjing Wang, Ph.D., have designed a new chemical tool that can detect the presence of opioids at a cellular level.

Antibody blocks dengue virus's NS1 protein from interacting with host cells
January 7, 2021

A team of researchers has discovered an antibody that blocks the dengue virus’s ability to cause disease in mice. The findings open the potential for developing effective treatments and designing a vaccine for dengue and similar diseases.

Anna Mapp, Ph.D.
December 18, 2020

Researchers are advancing a novel approach to developing antivirals against SARS-CoV-2, with support from the LSI’s Klatskin-Sutker Discovery Fund

Image credit: PNAS; (CC BY-NC-ND 4.0)
October 30, 2020

New research is challenging a long-held understanding of how two types of cellular proteins cooperate to activate genes. The findings improve the possibility of targeting these interactions with small-molecule drugs.

Shayamal Mosalaganti, Ph.D.
October 28, 2020

Shyamal Mosalaganti’s new research program at U-M will take advantage of the LSI’s cutting-edge cryo-ET resources to investigate how multi-protein cellular complexes perform their functions within the context of the cell environment — and how these functions contribute to health and disease.

Diogenes Lopez-Urioso
October 28, 2020

U-M program connects future scientists to the lab, the university and their goals

Regions of the Drosophila central nervous system that are activated in response to noxious stimulation
October 14, 2020

Researchers have uncovered a neural network that enables Drosophila melanogaster to convert external stimuli of varying intensities into a “yes or no” decision about when to act.

Artistic representation of budding yeast cells
September 10, 2020

Researchers have uncovered a new twist in the complex process cells use to transport their molecular cargo.

August 26, 2020

This year’s LSI Saltiel Life Sciences Symposium will examine innovative and creative research taking place to address scientific challenges across the biosciences. The two-day virtual event will offer a combination of full lectures and shorter talks from both external speakers and U-M investigators.

Rosa Vasquez and David Sherman collect samples at the Boiling River
June 30, 2020

Deep in the Peruvian Amazon Rain Forest, microorganisms are thriving within a river so hot, it boils. U-M graduate student Rosa Vásquez iexploring the Boiling River’s ecosystem, searching for genetic clues that explain how these organisms have evolved to survive in their scalding surroundings.

June 26, 2020

While many U-M labs were closed, new and current fellows in the Michigan Life Sciences Fellows program created opportunities to strengthen their network and develop professional skills.

Mouse neurons
June 16, 2020

New research reveals that one group of neurons controls various types of sighing, but they receive their instructions from different areas of the brain depending on the reason for the sigh.

Heat map of thermogenic fat cells (artistic rendering)
June 12, 2020

Researchers have discovered a new signaling pathway that prompts one type of fat cells to convert fat into heat.

Structural overview of BvnE
May 18, 2020

An international team of researchers has decoded the complex process that fungi use to build an important class of bioactive compounds.

May 13, 2020

Researchers have discovered how a protein that is overproduced by fat cells in an obese state may be contributing to the demise of two immune cell types — and driving further metabolic disorders in the process