Normal liver tissue and a liver cancer nodule containing many dividing cells.
August 15, 2022

A hormone secreted by fat cells can restrain the growth of liver tumors in mice, according to a new study from the LSI. The findings offer a proof-of-concept for developing therapies against the most common form of liver cancer.

July 26, 2022

Researchers have developed a method for altering one class of antibiotics, using microscopic organisms that produce these compounds naturally. The findings could lead to more efficient production of antibiotics that are effective against drug-resistant bacteria.

Voices of the LSI
June 28, 2022

"Voices of the LSI" is a quarterly column on the LSI’s work to cultivate a diverse, equitable and inclusive climate. This quarter, staff member Natalie Bartolacci, one of the institute's two DEI leads, reflects on what the LSI accomplished during its five-year "DEI 1.0" strategic effort and what lessons we can take into the next phase of our work to advance diversity, equity and inclusion.

Wenjing Wang and Kayla Kroning view cell imaging from a confocal micrscop
June 28, 2022

LSI Assistant Professor Wenjing Wang discusses the critical importance of supporting graduate students in the lab, and how philanthropic programs at the LSI are helping her students, and her entire research program, to thrive.

Melanie Ohi, Ph.D.
June 16, 2022

Researchers are pursuing a new potential culprit underlying Huntington’s disease, with an award from the Klatskin-Sutker Discovery Fund.

May 31, 2022

Scientists have identified a new role for a protein complex at the center of a human genetic disorder called Bardet-Biedl syndrome.

Voices of the LSI
March 15, 2022

"Voices of the LSI" is a quarterly column on the LSI’s work to cultivate a diverse, equitable and inclusive climate. This quarter, LSI Professor Bing Ye, Ph.D., considers scientific leaders' role in societal change and describes how trainees in his lab have helped expand his education and actions to advance diversity, equity and inclusion.

Artistic representation of biaryl bond formation through biocatalytic cross-coupling
March 2, 2022

Researchers have developed an efficient, greener strategy for constructing a common building block of many indispensable medicines and materials, using tools found in nature and sharpened in yeast.

 Wild type HeLa cells immunostained with antibodies against COMMD1 and VPS35
January 24, 2022

An obscure enzyme that normally operates deep within cells is also playing an unexpected role close to the cell surface—and is even required for cell migration—according to new research from the Life Sciences Institute.

Adipocytes (fat cells)
January 17, 2022

A new study led by the LSI demonstrates that blocking the activity of an enzyme inside fat cells can decrease obesity and related health disorders in mice.

Immunostaining of larval brains with and without overexpression of the protein Zelda
December 9, 2021

A team of scientists has identified a key player that drives both embryonic and neuronal stem cell fate, and demonstrated that this process must be precisely regulated to establish the developmental program in both embryo and neuronal tissues.

Voices of the LSI
December 1, 2021

"Voices of the LSI" is a quarterly column on the LSI’s work to cultivate a diverse, equitable and inclusive climate. In this column, Stephen Joy, Ph.D., reflects on his recent journey to share — and learn more about — his Japanese American family history and the challenges they faced during and after World War II.

A kinsesin bound to KIFBP
November 19, 2021

A new study has uncovered unexpected details about a key regulator kinesins, the molecular 'delivery trucks' that are essential for maintaining a healthy cellular supply chain.

Artistic representation of a brain with neurons connecting and firing
November 3, 2021

Scientists have identified how a protein in the brain uses information about the body’s energy balance to regulate growth rate and the onset of puberty in children.

September 26, 2021

University of Michigan faculty member Alison Narayan has received the American Chemical Society’s Arthur C. Cope Scholar Award for excellence in organic chemistry.

The common model species C. elegans can sense airbornewaves
September 22, 2021

A common model species can sense sound waves without ears, providing a new tool for studying auditory sensation.

Ciria Hernandez working in the Center for Chemical Genomics
July 29, 2021

Two new research projects are moving forward at the U-M Life Sciences Institute, with support from philanthropic funds established specifically to high-risk, high-reward research.

Voices of the LSI
July 7, 2021

A quarterly column on the LSI’s work to cultivate a diverse, equitable and inclusive climate

June 30, 2021

Researchers have demonstrated that a natural compound produced by lichens can block the activity of a protein that is central to the gene-activation process. The research, conducted in human-derived breast cancer cells, points to this protein as potential therapeutic target.

MC3R, AgRP and VGAT mRNA expression in the arcuate nucleus of a mouse brain
April 21, 2021

Scientists have identified a protein called the melanocortin 3 receptor as a potential drug target for treating obesity and eating disorders such as anorexia nervosa.

Artistic representation of a neural network
March 29, 2021

A new study from the University of Michigan offers insights into how neural circuitry in the brain operates and responds to feeding and hunger in real-time.

Mary Sue Coleman attends and LSI celebration in 2008
March 25, 2021

The building that houses the LSI will be named Mary Sue Coleman Hall. This naming recognizes her enduring commitment to the sciences and her role in spearheading the Life Sciences Institute, as well as her highly successful tenure as president of U-M.

Bing Ye discusses labwork with postdoctoral researcher Elizabeth Cebul
March 19, 2021

As we marked our first “Panniversary,” LSI professor and research associate dean Bing Ye reflected on how the institute has navigated a year of reduced research efforts, and the potential long-term impacts — both good and bad — on the scientific enterprise.

Cells fluorescing green in the presence of opioids
March 17, 2021

Researchers in the lab of Wenjing Wang, Ph.D., have designed a new chemical tool that can detect the presence of opioids at a cellular level.