Voices of the LSI
March 15, 2022

"Voices of the LSI" is a quarterly column on the LSI’s work to cultivate a diverse, equitable and inclusive climate. This quarter, LSI Professor Bing Ye, Ph.D., considers scientific leaders' role in societal change and describes how trainees in his lab have helped expand his education and actions to advance diversity, equity and inclusion.

Artistic representation of biaryl bond formation through biocatalytic cross-coupling
March 2, 2022

Researchers have developed an efficient, greener strategy for constructing a common building block of many indispensable medicines and materials, using tools found in nature and sharpened in yeast.

 Wild type HeLa cells immunostained with antibodies against COMMD1 and VPS35
January 24, 2022

An obscure enzyme that normally operates deep within cells is also playing an unexpected role close to the cell surface—and is even required for cell migration—according to new research from the Life Sciences Institute.

Adipocytes (fat cells)
January 17, 2022

A new study led by the LSI demonstrates that blocking the activity of an enzyme inside fat cells can decrease obesity and related health disorders in mice.

Immunostaining of larval brains with and without overexpression of the protein Zelda
December 9, 2021

A team of scientists has identified a key player that drives both embryonic and neuronal stem cell fate, and demonstrated that this process must be precisely regulated to establish the developmental program in both embryo and neuronal tissues.

Voices of the LSI
December 1, 2021

"Voices of the LSI" is a quarterly column on the LSI’s work to cultivate a diverse, equitable and inclusive climate. In this column, Stephen Joy, Ph.D., reflects on his recent journey to share — and learn more about — his Japanese American family history and the challenges they faced during and after World War II.

A kinsesin bound to KIFBP
November 19, 2021

A new study has uncovered unexpected details about a key regulator kinesins, the molecular 'delivery trucks' that are essential for maintaining a healthy cellular supply chain.

Artistic representation of a brain with neurons connecting and firing
November 3, 2021

Scientists have identified how a protein in the brain uses information about the body’s energy balance to regulate growth rate and the onset of puberty in children.

September 26, 2021

University of Michigan faculty member Alison Narayan has received the American Chemical Society’s Arthur C. Cope Scholar Award for excellence in organic chemistry.

The common model species C. elegans can sense airbornewaves
September 22, 2021

A common model species can sense sound waves without ears, providing a new tool for studying auditory sensation.

Ciria Hernandez working in the Center for Chemical Genomics
July 29, 2021

Two new research projects are moving forward at the U-M Life Sciences Institute, with support from philanthropic funds established specifically to high-risk, high-reward research.

Voices of the LSI
July 7, 2021

A quarterly column on the LSI’s work to cultivate a diverse, equitable and inclusive climate

June 30, 2021

Researchers have demonstrated that a natural compound produced by lichens can block the activity of a protein that is central to the gene-activation process. The research, conducted in human-derived breast cancer cells, points to this protein as potential therapeutic target.

MC3R, AgRP and VGAT mRNA expression in the arcuate nucleus of a mouse brain
April 21, 2021

Scientists have identified a protein called the melanocortin 3 receptor as a potential drug target for treating obesity and eating disorders such as anorexia nervosa.

Artistic representation of a neural network
March 29, 2021

A new study from the University of Michigan offers insights into how neural circuitry in the brain operates and responds to feeding and hunger in real-time.

Mary Sue Coleman attends and LSI celebration in 2008
March 25, 2021

The building that houses the LSI will be named Mary Sue Coleman Hall. This naming recognizes her enduring commitment to the sciences and her role in spearheading the Life Sciences Institute, as well as her highly successful tenure as president of U-M.

Bing Ye discusses labwork with postdoctoral researcher Elizabeth Cebul
March 19, 2021

As we marked our first “Panniversary,” LSI professor and research associate dean Bing Ye reflected on how the institute has navigated a year of reduced research efforts, and the potential long-term impacts — both good and bad — on the scientific enterprise.

Cells fluorescing green in the presence of opioids
March 17, 2021

Researchers in the lab of Wenjing Wang, Ph.D., have designed a new chemical tool that can detect the presence of opioids at a cellular level.

Antibody blocks dengue virus's NS1 protein from interacting with host cells
January 7, 2021

A team of researchers has discovered an antibody that blocks the dengue virus’s ability to cause disease in mice. The findings open the potential for developing effective treatments and designing a vaccine for dengue and similar diseases.

Anna Mapp, Ph.D.
December 18, 2020

Researchers are advancing a novel approach to developing antivirals against SARS-CoV-2, with support from the LSI’s Klatskin-Sutker Discovery Fund

Image credit: PNAS; (CC BY-NC-ND 4.0)
October 30, 2020

New research is challenging a long-held understanding of how two types of cellular proteins cooperate to activate genes. The findings improve the possibility of targeting these interactions with small-molecule drugs.

Shayamal Mosalaganti, Ph.D.
October 28, 2020

Shyamal Mosalaganti’s new research program at U-M will take advantage of the LSI’s cutting-edge cryo-ET resources to investigate how multi-protein cellular complexes perform their functions within the context of the cell environment — and how these functions contribute to health and disease.

Diogenes Lopez-Urioso
October 28, 2020

U-M program connects future scientists to the lab, the university and their goals

Regions of the Drosophila central nervous system that are activated in response to noxious stimulation
October 14, 2020

Researchers have uncovered a neural network that enables Drosophila melanogaster to convert external stimuli of varying intensities into a “yes or no” decision about when to act.