New research is challenging a long-held understanding of how two types of cellular proteins cooperate to activate genes. The findings improve the possibility of targeting these interactions with small-molecule drugs.
Shyamal Mosalaganti’s new research program at U-M will take advantage of the LSI’s cutting-edge cryo-ET resources to investigate how multi-protein cellular complexes perform their functions within the context of the cell environment — and how these functions contribute to health and disease.
U-M program connects future scientists to the lab, the university and their goals
Researchers have uncovered a neural network that enables Drosophila melanogaster to convert external stimuli of varying intensities into a “yes or no” decision about when to act.
Researchers have uncovered a new twist in the complex process cells use to transport their molecular cargo.
This year’s LSI Saltiel Life Sciences Symposium will examine innovative and creative research taking place to address scientific challenges across the biosciences. The two-day virtual event will offer a combination of full lectures and shorter talks from both external speakers and U-M investigators.
Deep in the Peruvian Amazon Rain Forest, microorganisms are thriving within a river so hot, it boils. U-M graduate student Rosa Vásquez iexploring the Boiling River’s ecosystem, searching for genetic clues that explain how these organisms have evolved to survive in their scalding surroundings.
While many U-M labs were closed, new and current fellows in the Michigan Life Sciences Fellows program created opportunities to strengthen their network and develop professional skills.
New research reveals that one group of neurons controls various types of sighing, but they receive their instructions from different areas of the brain depending on the reason for the sigh.
Researchers have discovered a new signaling pathway that prompts one type of fat cells to convert fat into heat.
An international team of researchers has decoded the complex process that fungi use to build an important class of bioactive compounds.
Researchers have discovered how a protein that is overproduced by fat cells in an obese state may be contributing to the demise of two immune cell types — and driving further metabolic disorders in the process
U-M scientists are advancing a new antibody test to identify people who have been infected with the novel coronavirus that causes the COVID-19 disease.
In the Michigan Life Sciences Fellows program, May-Walt Fellow Brittany Morgan, Ph.D., has found a balance of independence and community that will serve her well as she prepares for her independent scientific career. Learn how this 'super postdoc' program is helping fellows get a step ahead in their early careers and developing the next generation of scientific leaders.
An international team of researchers has unveiled the precise shape of a key player in human metabolism, which could open the door to better treatments for obesity and other metabolic disorders.
A new data-processing approach offers a simpler, faster path to data generated by cryo-electron microscopy instruments, removing a barrier to wider adoption of this powerful technique.
The University of Michigan and Sun Pharma Advanced Research Company (SPARC) have launched a partnership to accelerate the development of potential new medicines for a wide range of diseases.
The new director of Michigan Drug Discovery has big plans for how the initiative can continue to impact the university and the regional economy.
A new study reveals how an antiviral protein in our cells latches onto foreign invaders, and how some viruses — including HIV — evade capture.
Research investigator Isin Cakir, Ph.D., has been awarded the the 2019 Klatskin-Sutker Discovery Fund award to develop a suite of new molecules targeting obesity.
Researchers have shed light on the molecular details of a protein-protein interaction that drives cell movement and cancer metastasis
The LSI Cubed funding program is spurring innovative, trainee-led research projects, and already resulting in high-impact scientific findings.
Researchers have solved a nearly 50-year-old mystery of how fungi produce a large class of bioactive compounds, revealing a chemical reaction reaction that is nearly unprecedented in nature
Researchers have identified the first known cold-sensing protein to respond to extreme cold.